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WHO Classification of Tumours
Leiomyoma, NOS
Corpus uteri


Leiomyoma is a well-circumscribed benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern. Scattered adipocytes are a relatively common observation; a leiomyoma containing a striking number of adipocytes is termed a lipoleiomyoma.

Leiomyomas of the uterine corpus arise from the myometrium. They typically present as multiple, spherical firm nodules. Most frequently, they are intramural. Submucosal leiomyomas deform the overlying endometrium and may bulge into the endometrial cavity. They are frequently ulcerated and haemorrhagic. Subserosal leiomyomas can become pedunculated and may lose their attachment to the uterus. Degenerative changes are common. Most tumours are more cellular than the surrounding myometrium

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003