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WHO Classification of Tumours
Leiomyosarcoma, NOS
Corpus uteri


Definition

Leiomyosarcoma is an uncommon, aggressive malignant smooth muscle neoplasm, histologically characterized by a proliferation of neoplastic spindle cells. Morphologic variants include epithelioid leiomyosarcoma , myxoid leiomyosarcoma , granular cell and inflammatory leiomyosarcoma
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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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Leiomyosarcomas of the uterine corpus are typically solitary intramural masses with poorly defined margins. The diameter averages 8 cm. Zones of haemorrhage and necrosis are characteristic. The tumour may spread locally, regionally or by haematogenous dissemination. Local and regional spread may result in an abdominal or pelvic mass and gastrointestinal or urinary tract symptoms. The usual destination of haematogenous dissemination are the lungs.
Leiomyosarcoma is the most common pure uterine sarcoma. It principally arises in adults (median age 50-55 years). The tumour is highly malignant, the overall 5-year survival rate ranges from 15-25%. In most cases, recurrences are detected within two years. Major prognostic factor is the extent of tumour spread

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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