Endometrial stromal sarcoma, low grade
Low-grade endometrial stromal sarcoma is an infiltrating mesenchymal tumour arising from the uterine corpus, uterine cervix, vagina, and the ovary. It is typically densely cellular and characterized by the presence of oval to spindle-shaped cells that resemble the cells of the endometrial stroma, without evidence of significant atypia and pleomorphism. A rich network of thin-walled small vessels supports the cells. The tumour typically infiltrates deeply into the myometrium; about 50% of cases extend into the serosa.
Low-grade endometrial stromal sarcomas are usually indolent tumours. They have a propensity for late recurrence (>20 years in some cases). Resection, radiation therapy, progestin therapy or a combination thereof is frequently successful; 5-year survival ranges from 67% to nearly 100%
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