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WHO Classification of Tumours
Clear cell adenocarcinoma, NOS
Corpus uteri


Definition

Clear cell adenocarcinoma of the uterine corpus is a malignant neoplasm arising from the endometrium. It is composed mainly of clear or hobnail glandular epithelial cells. Various architectural patterns may be seen, including tubular, papillary, tubulocystic, and solid. The tumour cells are rich in glycogen and project into lumina and papillary spaces. The nuclei are large and highly pleomorphic. Occasionally, the cytoplasm is granular rather than clear.
Clear cell adenocarcinoma of the uterine corpus belongs to the group of non-estrogen-dependent tumours. It affects predominantly older patients and is frequently diagnosed in advanced clinical stages. The prognosis is poor

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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