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WHO Classification of Tumours
Serous cystadenocarcinoma, NOS
Corpus uteri


Serous adenocarcinoma is a high-grade primary adenocarcinoma arising from the endometrium. Histologically, it is characterized by invasive malignant glandular epithelium which often forms complex papillary structures with broad fibrovascular cores, cellular budding and sloughing of the cells. The cells are usually rounded. Multinucleated cells, mitoses, solid cell nests and foci of necrosis are common features. Approximately 30% of cases contain psammoma bodies. Serous adenocarcinomas belong to the group of non-estrogen-dependent tumours. A putative precursor lesion is serous endometrial intraepithelial carcinoma.
Serous adenocarcinomas are aggressive tumours with a tendency to deep myometrial and extensive lymphatic invasion. Extrauterine spread and recurrence are common and frequently result in death of the patient

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003