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WHO Classification of Tumours
Yolk sac tumor
Cervix uteri


Yolk sac tumour is a non-seminomatous malignant germ cell tumour composed of primitive germ cells. It is the most common malignant germ cell tumour in the pediatric population. The tumour mimics the yolk sac of the embryo and produces alpha-fetoprotein (AFP). This tumour is very responsive to chemotherapy regimens that include cisplatinum.

Cervical yolk sac tumours are polypoid, friable masses that protrude into the vagina. Patients typically present with abnormal vaginal bleeding

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003