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WHO Classification of Tumours
Melanoma, NOS
Cervix uteri


Definition

Malignant melanoma is a malignant, usually aggressive tumour composed of atypical, neoplastic melanocytes. Cutaneous melanomas may arise from acquired or congenital melanocytic or dysplastic nevi. Melanomas frequently metastasize to lymph nodes, liver, lungs, and brain
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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



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Histologic subtypes of malignant melanoma include:
Superficial spreading melanoma
Nodular melanoma
Acral lentiginous melanoma
Lentigo maligna melanoma

Malignant melanoma of the cervix is very rare. The tumours are usually polypoid or fungating, pigmented masses. Approximately 50% of cases contain a junctional component. Spindle-shaped cells are frequently present.
The tumour arises in adults. Patients typically present with abnormal vaginal bleeding. The prognosis is dismal

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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