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WHO Classification of Tumours
Cervix uteri


Adenomyoma is a benign neoplasm characterized by the presence of a glandular and a mesenchymal (fibromyomatous) component. It occurs predominantly in the uterine corpus and the cervix. The tumour typically presents as a polypoid submucosal lesion; rare cases may be intramural or subserosal.

Three variants of cervical adenomyoma have been described:

> Endocervical adenomyoma
Endocervical adenomyomas are composed of endocervical mucinous glands surrounded by smooth muscle. Large, mucin-secreting cells line the glands.

> Endometrial adenomyoma
This variant of cervical adenomyoma is composed of endometrialtype glands surrounded by endometrialtype stroma which is, in turn, surrounded by smooth muscle. The smooth muscle component predominates. Glands and stroma are bland.

> Atypical polypoid adenomyoma
In atypical polypoid adenomyoma the glandular component exhibits architectural complexity with or without cytological atypia.

Adenomyoma affects women of all ages. Simple polypectomy or local excision is usually curative

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003