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WHO Classification of Tumours
Malignant peripheral nerve sheath tumor
Cervix uteri


Definition

Malignant peripheral nerve sheath tumour (MPNST) is an uncommon, highly aggressive malignant tumour, arising from the peripheral nerves and affecting mostly adults in their third to sixth decades of life. It usually occurs in medium-sized and large nerves of the buttock, thigh, upper arm, or the paraspinal region. MPNST may be associated with neurofibromatosis type 1 (NF1).

Cervical MPNST is extremely rare. Fascicles of atypical spindle cells invade the cervical stroma and the surrounding endocervical glands. Myxoid paucicellular areas and densely cellular areas are characteristically intermixed. Patients typically present with vaginal bleeding or discharge. The prognosis is poor

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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