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WHO Classification of Tumours
Alveolar soft part sarcoma
Cervix uteri


Definition

A rare malignant neoplasm histologically characterized by the presence of large epithelioid cells with abundant cytoplasm forming nests and pseudoalveolar structures. Groups of the epithelioid cells are separated by thin-walled sinusoidal spaces. In adults the most common sites of involvement are the extremities, in infants and children the head and neck region. It usually presents as a slowly growing mass and it frequently metastasizes to other anatomic sites. The most common sites of metastasis are the lungs, bone, and brain
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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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Cervical alveolar soft part sarcoma presents as a polyp or an intramural nodule measuring <5cm in diameter. Patients typically present with abnormal uterine bleeding. Tumours arising in the female genital tract seem to have a better prognosis than their counterparts in other locations

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Nielsen GP, Oliva E, Young RH, Rosenberg AE, Dickersin GR, Scully RE (1995)
Alveolar soft-part sarcoma of the female genital tract: a report of nine cases and review of the literature.
Int J Gynecol Pathol 14: 283-92




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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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