Embryonal rhabdomyosarcoma, NOS
Rhabdomyosarcomas are the most frequent malignant soft tissue tumours in children and adolescents, with embryonal rhabdomyosarcoma as the most common subtype. Typical sites of involvement are the head and neck region and the genitourinary system. Phenotypically and biologically, embryonal rhabdomyosarcomas recapitulate features of embryonal skeletal muscle. Genetically, most cases show loss of chromosomal region 11p15
Alberto S. Pappo (Ed.)
Pediatric Bone and Soft Tissue Sarcomas
Springer Verlag: Berlin Heidelberg New York 2005
Cervical embryonal rhabdomyosarcoma (sarcoma botryoides) typically grows in a polypoid fashion. The polypoid masses may be pedunculated or sessile. They range in size from 2-10 cm. Small haemorrhagig areas as well as islands of mature neoplastic cartilage may be observed.
Sarcoma botryoides is rare. It usually arises in children and young adults (mean age 18 years). The prognosis is better than for other types of cervical sarcoma
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
IARC Press: Lyon 2003