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WHO Classification of Tumours
Adenocarcinoma in situ, NOS
Cervix uteri


Adenocarcinoma in situ is a non-invasice tumour in which the normally situated glands are partially or completely replaced by atypical cells with malignant features. The epithelium is usually stratified, lacks intracellular mucin, and may resemble endometrial epithelium. The cell nuclei are elongated, pleomorphic and hyperchromatic. Mitoses and prominent apoptosis are common. Endocervical, endometrioid and intestinal cell types may be observed. >50% of adenocarcinoma in situ are associated with cervical intraepithelial neoplasia (CIN).
The treatment of adenocarcinoma in situ is controversial, but conservative therapy seems to be effective in some cases

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003