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WHO Classification of Tumours
Clear cell adenocarcinoma, NOS
Cervix uteri


Clear cell adenocarcinoma is a malignant neoplasm composed of glandular epithelial clear cells. Various architectural patterns may be seen, including papillary, tubulocystic, and solid.

Clear cell adenocarcinoma arises rarely in the cervix. Postmenopausal women are most often affected. In young women, there is an association with in utero exposure to diethylstilbestrol (DES)

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Boyd J, Takahashi H, Waggoner SE, Jones LA, Hajek RA, Wharton JT, Liu FS, Fujino T, Barrett JC, McLachlan JA (1996)
Molecular genetic analysis of clear cell adenocarcinomas of the vagina and cervix associated and unassociated with diethylstilbestrol exposure in utero.
Cancer 77: 507-13

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003