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WHO Classification of Tumours
Signet ring cell carcinoma
Cervix uteri


Definition

Signet ring cell carcinoma is a usually aggressive, poorly differentiated invasive adenocarcinoma characterized by the presence of malignant glandular cells in which the nucleus is pressed to one side by the presence of intracytoplasmic mucus. In pure form, primary signet-ring cell adenocarcinoma is rare. Signet-ring cells are more commonly found focally in poorly differentiated mucinous adenocarcinomas and adenosquamous carcinomas
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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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