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WHO Classification of Tumours
Squamous cell carcinoma, microinvasive
Cervix uteri


Microinvasive (early invasive) squamous cell carcinoma (MSCC) is a variant of squamous cell carcinoma characterized by early stromal invasion. Early stromal invasion is an unmeasurable lesion <1 mm in depth. It can be managed in the same way as high grade cervical intraepithelial neoplasia (CIN). For the diagnosis of (MSCC), the depth of invasion must not exceed 3-5 mm.
Some features of high grade CIN increase the likelihood of early invasion, including: extensive CIN 3, widespread and deep extension into endocervical crypts, luminal necrosis, and intraepithelial squamous maturation

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al-Nafussi AI, Hughes DE (1994)
Histological features of CIN3 and their value in predicting invasive microinvasive squamous carcinoma.
J Clin Pathol 47: 799-804

. MSCC is usually associated with stromal oedema and a stromal desmoplastic and lymphocytic response. The risk of local lymph node metastasis is low
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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003