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WHO Classification of Tumours
Verrucous carcinoma, NOS
Cervix uteri


Definition

Verrucous carcinoma is a well differentiated histological variant of squamous cell carcinoma characterized by a papillary growth pattern, acanthosis, minimal nuclear atypia, and pushing tumour margins. The most commonly affected anatomic sites are the oral cavity, nasal cavity, larynx, esophagus, anus, vagina, vulva, and the plantar region of the foot.
Verrucous carcinoma of the uterine cervix shows no evidence of HPV infection. Cervical squamous cell carcinoma with a warty surface and cellular features of HPV infection is termed > warty or > condylomatous squamous cell carcinoma. In these tumours, high risk HPV-DNA is typically detected.
Verrucous carcinomas have a tendency to local recurrence after excision, but they do not metastasize

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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