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WHO Classification of Tumours
Squamous cell carcinoma, NOS
Cervix uteri


A carcinoma arising from squamous epithelial cells, morphologically characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells.
Typical sites of squamous cell carcinomas include the head and neck region, repiratory tract, skin and cervix.

Squamous cell carcinoma of the uterine cervix may be either predominantly exophytic and grow out from the surface, or it may be mainly endophytic and infiltrate the surrounding structures without much surface growth. Infiltrating tumours typically appear as irregular islands of anastomosing strands of neoplastic cells separated by cervical stroma. The stroma is usually invaded by a variety of cell types, especially lymphocytes and plasma cells. Cervical intraepithelial neoplasia (CIN) is frequently found on the surface and at the edge of the invasive carcinoma, particularly in small tumours

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003