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WHO Classification of Tumours
Cervical intraepithelial neoplasia, grade III
Cervix uteri


Definition

Squamous intraepithelial neoplasia is an epithelial neoplasm confined to the squamous epithelium, without invasion of the underlying tissues, but with malignant potential.
Cervical intraepithelial neoplasia (CIN) grade III is characterized by marked nuclear atypia and numerous, often abnormal, mitoses. Maturation may be absent or confined to the upper third of of the epithelium. The cells are solitary or arranged in syncytial aggregates. CIN represents the preinvasive counterpart of invasive cervical squamous cell carcinoma .
The risk of cervical intraepithelial neoplasia is highest in early reproductive life and is closely associated with the number of sexual partners and exposure to HPV

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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