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WHO Classification of Tumours
Melanocytic nevus
Vulva


Definition

Two types of melanocytic naevi occur in the vulva
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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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> Acquired melanocytic naevi appear during childhood and continue to grow with increasing age. The lesion may be junctional (epidermal-dermal), intradermal, or a compound of both.

> Atypical melanocytic naevi of the genital type are atypical melanocytic proliferations occurring predominantly in young women in the reproductive age. The lesions may be influenced by hormonal changes; during pregnancy, they may be more active or atypical. The tumours are small and well circumscribed. There is no significant atypia or mitotic activity in the deeper dermal melanocytes. Skin appendages are not involved

Click to access Pubmed
Clark WH, Hood AF, Tucker MA, Jampel RM (1998)
Atypical melanocytic nevi of the genital type with a discussion of reciprocal parenchymal-stromal interactions in the biology of neoplasia.
Hum Pathol 29: S1-24



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