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WHO Classification of Tumours
Nodular hidradenoma
Vulva


Definition

Hidradenoma is a benign epithelial neoplasm arising from the sweat glands. The tumour typically presents as a circumscribed, skin-coloured to red-brown nodule in the dermis of scalp, trunk, and proximal extremities; less commonly affected sites are hands, feet and eyelids. The lesion is composed of different types of cells: clear or pale cells; polygonal squamoid cells, often arranged in whorls; large mucinous cells; and cuboidal or columnar cells which line the tubules and show signs of apocrine differentiation. The cells are arranged in sheets that are interspersed with ducts and glandular areas. The stroma is often sclerotic and may be richly vascularized.
Hidradenomas are sporadic tumours that typically arise in adults (cases with childhood onset have been reported). Complete excision is curative

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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005



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