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WHO Classification of Tumours
Adenoma, NOS


A non-invasice, benign neoplasm arising from the epithelium. It may be encapsulated or non-encapsulated. The neoplastic epithelial cells may or may not display moderate cellular atypia or dysplasia.
Representative examples are pituitary gland adenoma, follicular adenoma of the thyroid gland, and adenomas (or adenomatous polyps) of the gastrointestinal tract.

In the vulva, adenomas are rare. They are composed of clusters of small, closely packed glands and tubules lined by columnar to cuboidal mucinous epithelium

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003

. Two subtypes are distinguished:

> Bartholin gland adenoma: The neoplastic structures are contiguous with Bartholin gland elements. Bartholin gland adenoma associated with adenoid cystic carcinoma has been reported

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Koenig C, Tavassoli FA (1998)
Nodular hyperplasia, adenoma, and adenomyoma of Bartholin's gland.
Int J Gynecol Pathol 17: 289-94


> Adenoma of minor vestibular glands: There are no intervening Bartholin duct elements associated with the lesion

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Axe S, Parmley T, Woodruff JD, Hlopak B (1986)
Adenomas in minor vestibular glands.
Obstet Gynecol 68: 16-8