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WHO Classification of Tumours
Adenocarcinoma, NOS


A common, malignant tumour characterized by the presence of malignant glandular cells. Morphologically, adenocarcinomas are classified according to the growth pattern (e.g., papillary, alveolar) or according to the secreted product (e.g., mucinous, serous).
Representative examples of adenocarcinoma are ductal and lobular breast carcinoma, lung adenocarcinoma, renal cell adenocarcinoma, hepatocellular carcinoma, colon adenocarcinoma, and prostate adenocarcinoma.

In the vulva, adenocarcinomas may arise at the site of the Bartholin gland

Click to access Pubmed
Leuchter RS, Hacker NF, Voet RL, Berek JS, Townsend DE, Lagasse LD (1982)
Primary carcinoma of the Bartholin gland: a report of 14 cases and review of the literature.
Obstet Gynecol 60: 361-8

, the Skene gland
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Sloboda J, Zaviacic M, Jakubovskŭ J, Hammar E, Johnsen J (1998)
Metastasizing adenocarcinoma of the female prostate (Skene's paraurethral glands). Histological and immunohistochemical prostate markers studies and first ultrastructural observation.
Pathol Res Pract 194: 129-36

, from endometriosis
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Bolis GB, Macciò T (2000)
Clear cell adenocarcinoma of the vulva arising in endometriosis. A case report.
Eur J Gynaecol Oncol 21: 416-7

or from ectopic cloacal tissue
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Willén R, Békássy , Carlén B, Bozoky B, Cajander S (1999)
Cloacogenic adenocarcinoma of the vulva.
Gynecol Oncol 74: 298-301

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Zaidi SN, Conner MG (2001)
Primary vulvar adenocarcinoma of cloacogenic origin.
South Med J 94: 744-6

. The tumours are usually solid and deeply infiltrative and may be mucinous, papillary or mucoepidermoid in type. Vulvar adenocarcinomas predominantly affect women >50 years of age
Click for details
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003