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WHO Classification of Tumours
Vulvar intraepithelial neoplasia, grade III
Vulva


Definition

Squamous intraepithelial neoplasia is a malignant epithelial neoplasm confined to the squamous epithelium, without invasion of the underlying tissues.

Vulvar intraepithelial neoplasia (VIN) usually presents as a macular or papular lesion. Approximately two thirds of cases are multifocal. The neoplastic squamous cells are typically crowded and characterized by disordered maturation and nuclear abnormalities. Acanthosis may be present. A prominent granular layer can be observed, which may be associated with parakeratosis, hyperkeratosis, or both.
Vulvar intraepithelial neoplasia most frequently affects women 20-35 years of age. Clinical symptoms include vulvar pruritus or irritation. VIN is associated with human papilloma virus (HPV) infection, most commonly type 16. The usual treatment is local excision. Risk factors for recurrence are heavy cigarette smoking and HIV infection

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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