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WHO Classification of Tumours
Squamous cell carcinoma, NOS


A carcinoma arising from squamous epithelial cells, morphologically characterized by the proliferation of atypical, often pleomorphic squamous cells. Squamous cell carcinomas are graded as well, moderately, or poorly differentiated. Well differentiated carcinomas are usually associated with keratin production and the presence of intercellular bridges between adjacent cells.
Typical sites of squamous cell carcinomas include the head and neck region, repiratory tract, skin and cervix.

In the vulva, squamous cell carcinoma is the most common malignant tumour. Older women are more frequently affected. Known risk factors are HPV infection and cigarette smoking. The tumour is typically solitary and may present as an ulcer, nodule, macule, or pedunculated mass, most commonly in on the labia minora or majora; approximately 10% of cases arise on the clitoris.
Poor prognostic factors include advanced stage, tumour diameter >2.5 cm, multifocality, capillary-like space involvement, associated squamous intraepithelial neoplasia (VIN) 2 or 3, and involved margins of resection

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003