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WHO Classification of Tumours
Invasive papillary carcinoma
Breast


Definition

Invasive micropapillary carcinoma of the breast is a rare variant of invasive ductal carcinoma composed of small clusters of neoplastic cells lying within prominent stromal spaces resembling dilated vascular channels. The neoplastic cells form papillary structures. Nuclear pleomorphism is moderate, mitoses are infrequent. The tumour typically presents as a solid, lobulated mass. Necrosis is absent, and there is no lymphocytic reaction.
Invasive micropapillary carcinomas affect predominantly women >40 years of age. The micropapillary growth pattern is correlated with vascular invasion and axillary lymph node metastases

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Nassar H, Wallis T, Andea A, Dey J, Adsay V, Visscher D (2001)
Clinicopathologic analysis of invasive micropapillary differentiation in breast carcinoma.
Mod Pathol 14: 836-41




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Paterakos M, Watkin WG, Edgerton SM, Moore DH, Thor AD (1999)
Invasive micropapillary carcinoma of the breast: a prognostic study.
Hum Pathol 30: 1459-63




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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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