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WHO Classification of Tumours
Follicular lymphoma


Follicular lymphoma (FL) is a neoplasm composed of follicle centre (germinal centre) B-cells (typically both centrocytes and centroblasts/large transformed cells), which usually has at least a partially
follicular pattern.
FL accounts for about 20% of all lymphomas, with the highest incidence in the USA and Western Europe. It affects predominantly adults, with a median age in the 6th decade and a male:female ratio of 1:1.7. FL rarely occurs in individuals under the age of 20 years.

Primary cutaneous follicle centre lymphomas are separately classified

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LeBoit PE, Burg G, Weedon D, Sarasin A (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Skin Tumours
3rd Edition
IARC Press: Lyon 2005

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Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, Vardiman JW (Eds.)
WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues
4th Edition
International Agency for Research on Cancer: Lyon 2008