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WHO Classification of Tumours
Leiomyosarcoma, NOS


Leiomyosarcoma is an uncommon, aggressive malignant smooth muscle neoplasm, histologically characterized by a proliferation of neoplastic spindle cells. Morphologic variants include epithelioid leiomyosarcoma , myxoid leiomyosarcoma , granular cell and inflammatory leiomyosarcoma
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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002


In the breast, smooth muscle tumours are uncommon; they account for <1% of breast tumours. Leiomyosarcoma most frequently affects adults from the 4th to the 7th decades of life, but cases have also been reported in adolescents and in patients >80 years old

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Falconieri G, Della Libera D, Zanconati F, Bittesini L (1997)
Leiomyosarcoma of the female breast: report of two new cases and a review of the literature.
Am J Clin Pathol 108: 19-25

. The lesion usually presents as a slow-growing, palpable, mobile, sometimes painful nodule measuring 0.5 to 15 cm. Recommended treatment is wide excision with tumour-free margins. Late local recurrence and metastasis may occur
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Chen KT, Kuo TT, Hoffmann KD (1981)
Leiomyosarcoma of the breast: a case of long survival and late hepatic metastasis.
Cancer 47: 1883-6

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Nielsen BB (1984)
Leiomyosarcoma of the breast with late dissemination.
Virchows Arch A Pathol Anat Histopathol 403: 241-5

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Munitiz V, Rios A, Canovas J, Ferri B, Sola J, Canovas P, Illana J, Parrilla P (2004)
Primitive leiomyosarcoma of the breast: case report and review of the literature.
Breast 13: 72-6

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003