Leiomyosarcoma is an uncommon, aggressive malignant smooth muscle neoplasm, histologically characterized by a proliferation of neoplastic spindle cells. Morphologic variants include epithelioid leiomyosarcoma
, myxoid leiomyosarcoma
, granular cell and inflammatory leiomyosarcoma
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IARC Press: Lyon 2002
In the breast, smooth muscle tumours are uncommon; they account for <1% of breast tumours. Leiomyosarcoma most frequently affects adults from the 4th to the 7th decades of life, but cases have also been reported in adolescents and in patients >80 years old
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. The lesion usually presents as a slow-growing, palpable, mobile, sometimes painful nodule measuring 0.5 to 15 cm. Recommended treatment is wide excision with tumour-free margins. Late local recurrence and metastasis may occur
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Leiomyosarcoma of the breast: a case of long survival and late hepatic metastasis.
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Leiomyosarcoma of the breast with late dissemination.
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IARC Press: Lyon 2003