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WHO Classification of Tumours
Leiomyoma, NOS


Leiomyoma is a well-circumscribed benign smooth muscle neoplasm histologically characterized by the presence of spindle cells with cigar-shaped nuclei, interlacing fascicles, and a whorled pattern.

In the breast, smooth muscle tumours are uncommon; they account for <1% of breast tumours. Leiomyoma most frequently affects adults from the 4th to the 7th decades of life, but cases have also been reported in adolescents and in patients >80 years old. Most leiomyomas arise from the areolar-nipple complex, a minority develop within the breast proper. The lesion usually presents as a slow-growing, palpable, mobile, sometimes painful nodule measuring 0.5 to 15 cm. Recommended treatment is complete excision

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003