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WHO Classification of Tumours
Rhabdomyosarcoma, NOS
Breast


Definition

Rhabdomyosarcoma is a rare aggressive mesenchymal tumour composed of cells with varying degrees of skeletal muscle differentiation.
Primary rhabdomyosarcoma in pure form is very uncommon in the breast. Most primary tumours are either of the alveolar or of the pleomorphic subtype; typically, the alveolar type arises in adolescents

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Hays DM, Donaldson SS, Shimada H, Crist WM, Newton WA, Andrassy RJ, Wiener E, Green J, Triche T, Maurer HM (1997)
Primary and metastatic rhabdomyosarcoma in the breast: neoplasms of adolescent females, a report from the Intergroup Rhabdomyosarcoma Study.
Med Pediatr Oncol 29: 181-9




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Rogers DA, Lobe TE, Rao BN, Fleming ID, Schropp KP, Pratt AS, Pappo AS (1994)
Breast malignancy in children.
J Pediatr Surg 29: 48-51



, whereas the pleomorphic type is observed in women >40 years of age
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Tavassoli FA
Pathology of the Breast
Appleton and Lange: Stanford 1992



. The majority of mammary rhabdomyosarcoma represent metastases from a soft tissue rhabdomyosarcoma occurring in children and young adults. These metastases are predominantly of the alveolar subtype
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Howarth CB, Caces JN, Pratt CB (1980)
Breast metastases in children with rhabdomyosarcoma.
Cancer 46: 2520-4




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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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