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WHO Classification of Tumours
Neurofibroma, NOS


An intraneural or extraneural neoplasm arising from nerve tissues and neural sheaths. It is composed of perineurial-like fibroblasts and Schwann cells. It usually presents as a localized cutaneous lesion and less often as a circumscribed peripheral nerve mass. Neurofibromas which arise from major nerves and plexiform neurofibromas are precursor lesions to malignant peripheral nerve sheath tumors.
Multiple neurofibromas are a hallmark of the neurofibromatosis type 1 (NF1) which is inherited by an autosomal dominant trait.

Primary neurofibroma is rare in the breast

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Sherman JE, Smith JW (1981)
Neurofibromas of the breast and nipple-areolar area.
Ann Plast Surg 7: 302-7

. Patients range in age from 15 to 80 years; women are more often affected than men
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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003