logo logo
Search: Organ site Search: Tumor / Syndrome
WHO Classification of Tumours
Desmoid-type fibromatosis


Fibromatosis of the breast is an uncommon, poorly demarcated, locally aggressive neoplasm originating from fibroblasts and myofibroblasts within the breast parenchyma. The neoplastic cells are spindle-shaped and arranged in interlacing fascicles. A characteristic feature are infiltrating finger-like projections at the periphery of the lesion which entrap mammary ducts and lobules. The tumour presents as a solitary, painless, firm, palpable mass measuring 0.5 to 10 cm (average 2.5 cm). It may be associated with skin or nipple retraction and rarely with nipple discharge. The mammographic appearance is that of a carcinoma.
Mammary fibromatosis is very rare (<0.2% of all breast lesions). It affects most commonly women in the childbearing age, but has been reported in patients from 13 to 80 years of age. A few cases have been found in men. The tumour has no metastatic potential. The tendency for local recurrence is around 25% and thus significantly lower than for extramammary fibromatoses (around 57%)

Click to access Pubmed
Wargotz ES, Norris HJ, Austin RM, Enzinger FM (1987)
Fibromatosis of the breast. A clinical and pathological study of 28 cases.
Am J Surg Pathol 11: 38-45

Click to access Pubmed
Rosen PP, Ernsberger D (1989)
Mammary fibromatosis. A benign spindle-cell tumor with significant risk for local recurrence.
Cancer 63: 1363-9

Click to access Pubmed
Glazebrook KN, Reynolds CA (2009)
Mammary fibromatosis.
AJR Am J Roentgenol 193: 856-60

Click for details
Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003