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WHO Classification of Tumours
Haemangiopericytoma
Breast


Definition

Haemangiopericytoma (HPC) is a mesenchymal tumour histologically characterized by dilated vascular spaces, often with a staghorn or bifed shape. Individual tumour cells are surrounded by a reticulin network and are positive for CD34 and CD99. Haemangiopericytomas closely resemble cellular areas of solitary fibrous tumour (SFT) and and are closely related to, if not synonymous with, SFT. Lesions formerly known as infantile HPC fall within the spectrum of infantile myofibromatosis
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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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Haemangiopericytoma of the breast is a rare tumour with only around 20 reported primary cases. It affects predominantly adult women, but occasional cases occur in children and in men

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Tavassoli FA, Weiss S (1981)
Hemangiopericytoma of the breast.
Am J Surg Pathol 5: 745-52




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Arias-Stella J, Rosen PP (1988)
Hemangiopericytoma of the breast.
Mod Pathol 1: 98-103




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Talwar S, Prasad N, Gandhi S, Prasad P (1999)
Haemangiopericytoma of the adult male breast.
Int J Clin Pract 53: 485-6



. The tumour typically presents as a round to oval, well circumscribed mass measuring 1-19 cm. Myxoid areas alternating with small cysts filled with a watery fluid can be observed macroscopically. Larger tumours may contain areas of haemorrhage and necrosis. Histologically, haemangiopericytoma is characterized by a compact proliferation of bland ovoid to spindle-shaped cells around branching vessels. Focally trapped mammary ducts and ductules are often found at the periphery of the lesion.
The majority of mammary haemangiopericytoma are benign; recurrence or metastases have not been reported. Wide local excision is often sufficient

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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