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WHO Classification of Tumours
Hemangioma, NOS


Haemangioma of the breast is a benign, well circumscribed vascular neoplasm measuring 0.5-2 cm. Histologically, three subtypes are distinguished:

> Cavernous haemangioma is the most common subtype. It is composed of dilated thin vessels which are bordered by flattened endothelium and filled with blood. Thrombosis and papillary endothelial hyperplasia may be observed. Organizing thrombi and/or the stroma between the vascular channels may show dystrophic calcification

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Sebek BA (1984)
Cavernous hemangioma of the female breast.
Cleve Clin Q 51: 471-4


> Capillary haemangioma is characterized by nodules of small vessels arranged in a lobular pattern around a larger feeding vessel and embedded within fibrous stroma. The endothelial cells lining the vessels may contain prominent hyperchromatic nuclei, but tufting or a solid spindle cell growth pattern are absent.

> Venous haemangiomas are composed of thick vascular channels walled by smooth muscle of varying thickness

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Rosen PP, Jozefczyk MA, Boram LH (1985)
Vascular tumors of the breast. IV. The venous hemangioma.
Am J Surg Pathol 9: 659-65


Haemangiomas of the breast occur in both male and female patients from 18 months to 82 years old. Rarely, patients present with palpable lesions. Non-palpable cases are mainly detected by imaging. Recurrence after excision has not been reported

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Jozefczyk MA, Rosen PP (1985)
Vascular tumors of the breast. II. Perilobular hemangiomas and hemangiomas.
Am J Surg Pathol 9: 491-503

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003