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WHO Classification of Tumours


Adenomyoepithelioma is a usually benign neoplasm of the breast characterized by the proliferation of myoepithelial cells around spaces which are lined by epithelial cells. The growth pattern is most frequently lobulated, but may also be tubular or spindle cell. In lobulated lesions, fibrous septae with central hyalinization or infarction are common. Tubular lesions have ill defined margins. In rare cases, the epithelial and/or myoepithelial cells may undergo malignant transformation and give rise to a carcinoma. The malignant myoepithelial cells may assume a spindle configuration and form nodules resembling myofibroblastic lesions. Benign lesions present as rounded nodules with a median size of 2.5 cm.
Adenomyoepithelioma occurs in adults of all age groups. Most lesions are benign. Cases with malignant transformation may follow an aggressive clinical course, including recurrences and local and distant metastases

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003