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WHO Classification of Tumours
Pleomorphic adenoma


Pleomorphic adenoma is a neoplasm characterized by the presence of benign epithelial and myoepithelial cells and a mesenchymal component that may contain mucoid, myxoid, cartilaginous, or osseous areas. It may be completely or partially encapsulated. It usually presents as a slowly growing painless mass. It may recur after excision or transform to a malignant carcinoma ex pleomorphic adenoma .

Pleomorphic adenoma of the breast is rare. It occurs over a wide range of age and affects predominantly women. Multiple lesions have been reported

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Ballance WA, Ro JY, el-Naggar AK, Grignon DJ, Ayala AG, Romsdahl MG (1990)
Pleomorphic adenoma (benign mixed tumor) of the breast. An immunohistochemical, flow cytometric, and ultrastructural study and review of the literature.
Am J Clin Pathol 93: 795-801

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Chen KT (1990)
Pleomorphic adenoma of the breast.
Am J Clin Pathol 93: 792-4

. Because of its chondroid stromal component, the lesion may be misinterpreted as a malignant tumour
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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003