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WHO Classification of Tumours
Intracystic papillary carcinoma


Intracystic papillary carcinoma is a variant of intraductal papillary carcinoma proliferating within a large cystic duct. It is histologically characterized by thin fibrovascular stalks covered by neoplastic epithelial cells showing features typical for low grade ductal carcinoma in situ (DCIS); features of intermediate or high grade DCIS are less common. An intermediary myoepithelial cell layer is absent.
Solid and transitional cell variants have been described. The solid variant is characterized by production of mucin, association with mucinous carcinoma and frequently a spindle cell population. In the transitional cell variant, sheets of transitional type cells overlie the fibrovascular cores.
Intracystic papillary carcinomas are rare (<2% of breast carcinomas). They range in size from 0.4 to 10 cm (mean, 2 cm). The mean age at clinical manifestation is approximately 65 years

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003