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WHO Classification of Tumours
Intraductal papillary carcinoma
Breast


Definition

Intraductal papillary carcinoma is a non-invasive breast adenocarcinoma located in a distended duct. It is characterized by the presence of papillary structures with fibrovascular stalks. Diagnostic criteria are the absence of a myoepithelial cell layer in 90% or more of the papillary processes and/or a pattern of low grade ductal carcinoma in situ (DCIS) occupying 90% or more of the lesion. Intraductal papillary carcinomas can be either solitary and centrally located as intracystic papillary carcinomas , or multifocal within the terminal duct lobular unit (TDLU), corresponding to the papillary type of DCIS.
In the absence of ductal carcinoma in situ or invasive carcinoma in adjacent tissues, the prognosis is favourable. Lymph node metastases or disease-related deaths have not been reported. Complete excision and thorough assessment of tumour tissue and surrounding breast tissue is imperative

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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