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WHO Classification of Tumours
Glycogen-rich carcinoma
Breast


Definition

Glycogen-rich, clear cell carcinoma (GRCC) is a breast carcinoma characterized by the presence of abundant clear cytoplasm containing glycogen in more than 90% of the neoplastic cells. The cell nuclei are hyperchromatic and have prominent nucleoli. The clinical and macroscopical features of GRCC are similar to those of infiltrating duct carcinoma . Tumour size ranges from 1 to 8 cm. The borders may be circumscribed or infiltrative. The in situ component of the tumour has a compact solid, comedo or papillary growth pattern. The invasive part generally consists of solid nests; tubular or papillary structures are rare.
Glycogen-rich, clear cell carcinomas account for 1-3% of breast carcinomas. They affect patients from 41-78 years of age (median 57 years). The reported data suggest that GRCCs are more aggressive than typical ductal carcinomas and show a greater tendency for axillary lymph node invasion

Click to access Pubmed
Hull MT, Warfel KA (1986)
Glycogen-rich clear cell carcinomas of the breast. A clinicopathologic and ultrastructural study.
Am J Surg Pathol 10: 553-9




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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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