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WHO Classification of Tumours
Acinar cell carcinoma


Acinar cell carcinoma (ACCA) is a malignant glandular epithelial neoplasm consisting of secretory cells forming acinar patterns. The tumour presents as a palpable nodule measuring between 2 and 5 cm. Histologically, it is characterized by solid, microcystic and microglandular areas. The neoplastic cells have abundant, usually granular, amphophilic to eosinophilic cytoplasm and irregular nuclei with a single nucleolus.
Acinar cell carcinoma of the breast is a rare tumour with very few reported cases

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Damiani S, Pasquinelli G, Lamovec J, Peterse JL, Eusebi V (2000)
Acinic cell carcinoma of the breast: an immunohistochemical and ultrastructural study.
Virchows Arch 437: 74-81

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Schmitt FC, Ribeiro CA, Alvarenga S, Lopes JM (2000)
Primary acinic cell-like carcinoma of the breast--a variant with good prognosis?
Histopathology 36: 286-9

. Patients are between 35 and 80 years of age (mean age 56 years). Axillary lymph node metastases may occur
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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003