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WHO Classification of Tumours
Oxyphilic adenocarcinoma


Oxyphilic or oncocytic adenocarcinoma is a rare breast carcinoma composed to >70% of oncocytic cells. Oncocytes, or "swollen cells", are characterized by a cytoplasm occupied to 60% by diffusely dispersed mitochondria. Oncocytic adenocarcinomas have defined, circumscribed borders and vary from glandular to solid. The neoplastic cells have round to ovoid nuclei with a conspicuous nucleolus; the cytoplasm is filled with small eosinophilic granules. Mitoses are infrequent.
Only a few cases of oncocytic adenocarcinoma have been reported; all patients were older than 60 years

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Damiani S, Eusebi V, Losi L, D'Adda T, Rosai J (1998)
Oncocytic carcinoma (malignant oncocytoma) of the breast.
Am J Surg Pathol 22: 221-30

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Costa MJ, Silverberg SG (1989)
Oncocytic carcinoma of the male breast.
Arch Pathol Lab Med 113: 1396-9

. More studies are necessary to allow for a meaningful discussion of prognosis
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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003