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WHO Classification of Tumours
Lipid-rich carcinoma
Breast


Definition

Lipid-rich carcinoma is a carcinoma of the breast characterized by abundant amounts of neutral lipids in the cytoplasm of approximately 90% of the malignant epithelial cells. The tumours typically present as palpable nodules which range in size from 1.2 to 15 cm
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Wrba F, Ellinger A, Reiner G, Spona J, Holzner JH (1988)
Ultrastructural and immunohistochemical characteristics of lipid-rich carcinoma of the breast.
Virchows Arch A Pathol Anat Histopathol 413: 381-5



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Patients are between 33 and 81 years old and typically female; one case has been reported in a 55-year old man

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Mazzella FM, Sieber SC, Braza F (1995)
Ductal carcinoma of male breast with prominent lipid-rich component.
Pathology 27: 280-3



. A positive correlation of lipid content with high histological grade has been found
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Fisher ER, Gregorio R, Kim WS, Redmond C (1977)
Lipid in invasive cancer of the breast.
Am J Clin Pathol 68: 558-61



. Extensive lymph node metastases occur in a majority of cases
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Ramos CV, Taylor HB (1974)
Lipid-rich carcinoma of the breast. A clinicopathologic analysis of 13 examples.
Cancer 33: 812-9



. The prognosis remains uncertain due to the heterogeneity of the reported lesions and very short follow-up periods
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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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