Medullary carcinoma, NOS
Medullary carcinoma (MC) of the breast is a malignant epithelial tumour characterized by a syncytial growth pattern. The poorly differentiated neoplastic cells are arranged in large sheets and contain abundant eosinophilic cytoplasm and large, vesicular nuclei with prominent nucleoli. Mitoses are numerous. There is a prominent intraepithelial infiltrate of lymphocytes. Glandular/tubular structures are absent. The stroma is scant. The tumours are well circumscribed and have a median diameter from 2 to 2.9 cm. Foci of necrosis and haemorrhage are frequent.
MC typically lacks estrogen receptor expression.
The mean age of patients ranges from 45 to 52 years. The prognosis for typical medullary carcinoma is very favourable, with a 10-year disease-free survival of >90%. Distant metastases are rare
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