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WHO Classification of Tumours
Cribriform carcinoma, NOS
Breast


Definition

Invasive cribriform carcinoma (ICC) of the breast is characterized by invasive islands of tumour cells exhibiting a cribriform growth pattern. Apical snouts are typical. The neoplastic cells are small and show low to moderate nuclear pleomorphism. Mitoses are rare. A prominent fibroblastic stroma is often present. Clinically, ICC may present as a mass but is frequently occult. Mammography typically shows a spiculated mass, often containing microcalcifications
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Stutz JA, Evans AJ, Pinder S, Ellis IO, Yeoman LJ, Wilson AR, Sibbering DM (1994)
The radiological appearances of invasive cribriform carcinoma of the breast. Nottingham Breast Team.
Clin Radiol 49: 693-5



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All ICCs are estrogen receptor positive and approximately 70% are progesterone receptor positive

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Venable JG, Schwartz AM, Silverberg SG (1990)
Infiltrating cribriform carcinoma of the breast: a distinctive clinicopathologic entity.
Hum Pathol 21: 333-8



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Invasive cribriform carcinoma is rare (0.8-3.5% of breast carcinomas). It affects older women (mean age 53-58 years). The prognosis is very favourable, with a ten-year survival of 90-100%. Axillary lymph node metastases occur in approximately 15% of cases

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Page DL, Dixon JM, Anderson TJ, Lee D, Stewart HJ (1983)
Invasive cribriform carcinoma of the breast.
Histopathology 7: 525-36




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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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