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WHO Classification of Tumours
Tubular adenocarcinoma
Breast


Definition

Tubular adenocarcinoma of the breast is characterized by distinct, well differentiated tubular structures composed of a single layer of epithelial cells enclosing clear lumina. Most tubules are oval or rounded, and some typically appear angulate. They are accompanied by a cellular desmoplastic stroma. The neoplastic cells are small and regular and exhibit little nuclear pleomorphism. Mitoses are infrequent. The tumours are usually small (0.2-2cm in diameter). Two morphological subtypes are distinguished: The pure type shows a pronounced stellate configuration with radiating arms, while the structure of the sclerosing type is more diffuse and ill defined
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Parl FF, Richardson LD (1983)
The histologic and biologic spectrum of tubular carcinoma of the breast.
Hum Pathol 14: 694-8



. The majority of tubular carcinomas are associated with ductal carcinoma in situ.
Almost all tubular carcinomas are estrogen- and progesteron-receptor positive and ERBB2 and EGFR negative.
The incidence of tubular carcinoma of the breast rises with age. The tumour typically affects postmenopausal women. The prognosis of pure tubular carcinoma is excellent. Recurrence after breast conservation treatment is rare and axillary node metastases are infrequent

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Diab SG, Clark GM, Osborne CK, Libby A, Allred DC, Elledge RM (1999)
Tumor characteristics and clinical outcome of tubular and mucinous breast carcinomas.
J Clin Oncol 17: 1442-8




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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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