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WHO Classification of Tumours
Undifferentiated carcinoma with osteoclast-like cells
Breast


Definition

Carcinoma with osteoclast-like giant cells is a rare, usually aggressive variant of infiltrating duct carcinoma, NOS characterized by the presence of osteoclastic giant cells in the tumour stroma. The stroma is typically inflammatory, fibroblastic, and hypervascular.
Lymph node metastases have been found in about one-third of the reported cases. Five year survival is around 70%

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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003



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