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WHO Classification of Tumours
Liposarcoma, NOS


Liposarcoma is a malignant tumour composed entirely or in part of neoplastic adipocytes.
There are five variants that differ in morphology, clinical manifestation, genetic profile and prognosis:
Variant/synonymFraction of liposarcomasAgeLocationMetastasisGenetics
Well differentiated liposarcoma / Atypical lipomatous tumour40-50%Adults; peak 6th decadeLimbs (thigh), retroperitoneum, paratesticular area, mediastinumOnly after dedifferentiation (<10% of cases)Supernumerary ring and giant marker chromosomes, MDM2 amplification
Dedifferentiated liposarcoma <10%AdultsRetroperitoneum, limbsYes, in 15-20% of casesSupernumerary ring and giant marker chromosomes; multiple abnormal clones
Myxoid liposarcoma /Round cell liposarcoma30-35%Peak 4th-5th decadeMusculature of the thigh; deep soft tissues (limbs)Yes, in approx. 1/3 of casesTranslocation t(12;16)(q13;p11) in 90% of cases
Pleomorphic liposarcom Approx. 5%Adults > 50 yearsLower limbs > upper limbsYes, in 30-50% of casesComplex rearrange-ments, with ring, giant marker and double minute chromosomes
Mixed-type liposarcoma Very rare> 60 yearsRetroperitoneum, abdomenYesRing and giant marker chromosomes, 12q14-15 amplification (MDM2)

Primary liposarcoma of the breast affects predominantly women from 19-76 years of age (median, 47 years); male patients are rare. The tumour typically presents as a slowly enlarging, painful mass with a median size of 8 cm. Practically all variants of soft tissue liposarcoma may occur in the breast

Click to access Pubmed
Austin RM, Dupree WB (1986)
Liposarcoma of the breast: a clinicopathologic study of 20 cases.
Hum Pathol 17: 906-13

. The tumour behaves particularly aggressively when associated with pregnancy
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Tavassoli FA, Devilee P (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of the Breast and Female Genital Organs.
3rd Edition
IARC Press: Lyon 2003