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WHO Classification of Tumours
Connective, subcutaneous and other soft tissues


Lipoblastoma and lipoblastomatosis are benign, relatively small (2-5cm) tumours resembling fetal adipose tissue. They most commonly affect the extremities.

> Lipoblastoma is a localized, well circumscribed tumour with a lobulated appearance, confined to the subcutis.The lobules are separated by connective tissue septa.

> Lipoblastomatosis is a diffuse tumour which infiltrates the deeper muscle. The lobulation is less pronounced.

In the vast majority of cases, rearrangement of 8q11-13 has been observed. Lipoblastoma and lipoblastomatosis are most commonly found in the first three years of life; males are more frequently affected. Both tumour types are benign. Lipoblastomatosis shows a tendency to recur; wide surgical excision of diffuse tumours is therefore recommended

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002