Connective, subcutaneous and other soft tissues
Lipoblastoma and lipoblastomatosis are benign, relatively small (2-5cm) tumours resembling fetal adipose tissue. They most commonly affect the extremities.
> Lipoblastoma is a localized, well circumscribed tumour with a lobulated appearance, confined to the subcutis.The lobules are separated by connective tissue septa.
> Lipoblastomatosis is a diffuse tumour which infiltrates the deeper muscle. The lobulation is less pronounced.
In the vast majority of cases, rearrangement of 8q11-13 has been observed. Lipoblastoma and lipoblastomatosis are most commonly found in the first three years of life; males are more frequently affected. Both tumour types are benign. Lipoblastomatosis shows a tendency to recur; wide surgical excision of diffuse tumours is therefore recommended
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
IARC Press: Lyon 2002