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WHO Classification of Tumours
Pleomorphic liposarcoma
Connective, subcutaneous and other soft tissues


Definition

Pleomorphic liposarcoma is a high grade pleomorphic sarcoma histologicaly characterized by the presence of pleomorphic, multivacuolated lipoblasts admixed with multinucleated giant cells (resembling malignant fibrous histiocytoma ). Areas of atypical lipomatous tumour (well differentiated liposarcoma ) or malignant mesenchymoma are absent. Myxoid change and areas of necrosis are common.
Pleomorphic liposarcomas are typically large, firm, often multinodular lesions. The tumour mainly arises in deep soft tissues; most frequently affected sites are the extremities

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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Pleomorphic liposarcoma is the rarest liposarcoma variant. Most patients are >50 years old. The clinical course is usually aggressive. Metastases develop in 30-50% of cases, preferentially to the lung. Tumour-associated mortality is 40-50%

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Zagars GK, Goswitz MS, Pollack A (1996)
Liposarcoma: outcome and prognostic factors following conservation surgery and radiation therapy.
Int J Radiat Oncol Biol Phys 36: 311-9




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Downes KA, Goldblum JR, Montgomery EA, Fisher C (2001)
Pleomorphic liposarcoma: a clinicopathologic analysis of 19 cases.
Mod Pathol 14: 179-84



; many patients die within a short period of time
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Miettinen M, Enzinger FM (1999)
Epithelioid variant of pleomorphic liposarcoma: a study of 12 cases of a distinctive variant of high-grade liposarcoma.
Mod Pathol 12: 722-8




Click for details
Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



.