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WHO Classification of Tumours
Well differentiated liposarcoma
Connective, subcutaneous and other soft tissues


Definition

Well differentiated liposaroma (WDL) is a locally agressive mesenchymal neoplasm that consists of mature neoplastic adipocytes, with foci that show significant cellular and nuclear atypia both in adipocytes and stromal cells.
WDL does not metastasize, except in cases with progressve dedifferentiation. In surgically amenable locations excision is usually curative.
The terms well differentiated liposarcoma (WDL) and atypical lipomatous tumour (ALT) are used synonymously. The latter term is mainly used for easily accesible tumours for which surgical excision is often curative. This term is, therefore, mainly used in the clinical setting

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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