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WHO Classification of Tumours
Embryonal rhabdomyosarcoma, NOS
Connective, subcutaneous and other soft tissues


Definition

Rhabdomyosarcomas are the most frequent malignant soft tissue tumours in children and adolescents, with embryonal rhabdomyosarcoma as the most common subtype. Typical sites of involvement are the head and neck region and the genitourinary system. Phenotypically and biologically, embryonal rhabdomyosarcomas recapitulate features of embryonal skeletal muscle. Genetically, most cases show loss of chromosomal region 11p15
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Alberto S. Pappo (Ed.)
Pediatric Bone and Soft Tissue Sarcomas
1st Edition
Springer Verlag: Berlin Heidelberg New York 2005



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Three histological variants of embryonal rhabdomyosarcoma have been identified

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Fletcher CDM, Unni KK, Mertens F (Eds.)
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone.
3rd Edition
IARC Press: Lyon 2002



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Spindle cell rhabdomyosarcoma
Botryoid rhabdomyosarcoma
Anaplastic rhabdomyosarcoma